Bills RB LeSean McCoy (thumb) practiced for the 2nd straight day on Thursday. RB Mike Gillislee, meanwhile, sat out after tweaking his hamstring on Wednesday. At this point, it looks like McCoy has the better chance of playing against the Jaguars this weekend. We'll have another update on both guys tomorrow.

The Bills announced Karlos Williams as their starting RB for today's game against the Cowboys.  ESPN's Mike Rodak cautions that RB Mike Gillislee will remain involved, but Williams is clearly the better bet for touches and the better fantasy play.  Buffalo should be able to run it plenty in this one, giving the explosive rookie RB1 upside.