Chargers Edge Khalil Mack is questionable for the second straight week thanks to a groin injury that kept him out of practice once again. Mack missed all three practices last week before playing through a "questionable" tag last week. He made it through just 4 snaps in that game. Edge Joey Bosa, meanwhile, put in his first full practice since Week 3 on Friday and is off the final injury report for the first time since that week as well. He said Friday that they plan to increase his playing time from the 19-20 snaps of the past three games to "about 30, 30-plus."

In another clear sign that the Titans are surrendering Thursday night's game to the Cowboys, the team announced Wednesday that basically the entire defense is out or doubtful. DT Jeffery Simmons, S Amani Hooker, EDGE Bud Dupree, LB Dylan Cole and LB Zach Cunningham are out. DL Denico Autry and CB Kristian Fulton are doubtful, which is really just a wishy-washy way of saying "out." LB Monty Rice, CB Roger McCready and S Andrew Adams like just about the only playable pieces for IDP leagues.

The Titans have ruled S Amani Hooker (shoulder) and EDGE Bud Dupree (hip) out for Thursday night's game against the Packers. DT Jeffery Simmons (ankle) is questionable. He missed Sunday's win over the Broncos but returned for limited practices the past 2 days. Simmons seems to be trending toward returning for this game and will be worth using in IDP lineups if available.

The Titans have ruled DT Jeffery Simmons (ankle) out for Sunday's game against the Broncos, along with starters S Amani Hooker (shoulder), EDGE Bud Dupree (hip) and LB Zach Cunningham (elbow). Simmons is the biggest loss, both for the run defense and the pass rush. He had played through the sprain the past 2 games -- including for 81 snaps in last week's OT loss to the Chiefs. He said this week that he aggravated the ankle in that game. We'll see whether he can make it back for a Week 11 trip to Green Bay.