Texans RB Joe Mixon (ankle) remained sidelined for Wednesday's practice. HC Demeco Ryans labeled him "week to week" on Monday, so fantasy owners should not be expecting Mixon back for this weekend's game vs. the Patriots. RB Dameon Pierce (hamstring) was limited on Wednesday and is on track to return for Sunday's game. In that case, you should avoid Houston's backfield in Week 6 fantasy lineups.

Texans HC Demeco Ryans said Monday that RB Joe Mixon (ankle) is "definitely improving" but wouldn't say whether Mixon will be back for this weekend's game vs. the Patriots. Mixon returned to Friday's practice ahead of Week 4 but did not practice at all this past week, so it looks like he suffered a setback.

Texans RB Dameon Pierce (hamstring) is inactive for today's game vs. the Bills. That again leaves the backfield to Cam Akers, Dare Ogunbowale, and J.J. Taylor. Akers figures to lead in touches but ceded carries to Taylor and passing-down snaps to Ogunbowale last week.

Texans RB Dameon Pierce (hamstring) is not expected to play vs. the Bills today, according to ESPN's Adam Schefter. Pierce just returned to a limited practice on Friday after missing the last three games, so it's no surprise that he's not ready yet. With RB Joe Mixon (ankle) also out, Houston will again roll with RBs Cam Akers, Dare Ogunbowale, and J.J. Taylor.