ESPN's Adam Schefter reports that 49ers RB Isaac Guerendo is "unlikely to play" Sunday at Miami because of his hamstring injury.

49ers RB Isaac Guerendo (foot) is active for tonight's game vs. the Rams. He was listed as questionable after only getting in a limited practice on Tuesday. But Guerendo downplayed the injury throughout the week and was reportedly expected to play tonight even before getting through warmups. There have been no reports so far about the rookie's expected workload in this one. He shapes up as a risk/reward fantasy play. Check the new-and-improved Who To Start Tool to see if Guerendo makes sense for your starting lineup. RBs Patrick Taylor and Ke'Shawn Vaughn are also active for San Francisco tonight; RB Israel Abanikanda is a healthy scratch.

49ers RB Isaac Guerendo suffered a foot injury in the fourth quarter of Sunday's game vs. the Bears. He's officially questionable to return. Guerendo was controlling work in the backfield before exiting, carrying 15 times for 78 yards and two scores and catching both of his targets for 50 yards. His absence leaves San Francisco with RBs Patrick Taylor and Israel Abanikanda.

The 49ers claimed RB Israel Abanikanda off waivers from the Jets. The 2023 fifth-rounder never found playing time in New York, carrying 22 times last year and 0 this season. He was an intriguing prospect coming out of Pittsburgh, though, after leading the ACC in carries (239) and rushing yards (1,431) as a true junior in 2022. Abanikanda is still only 22 years old. He joins a 49ers backfield that just lost RBs Christian McCaffrey and Jordan Mason for the rest of the fantasy season. Rookie Isaac Guerendo is set to step in as the lead back, while Patrick Taylor will likely be the No. 2. Abanikanda is ultimately a long shot for reliable fantasy value this season, but he's at least worth monitoring over the next couple of weeks.