49ers WR Jauan Jennings caught seven of his eight targets for 90 yards and two TDs. Teammate Deebo Samuel had a rougher go of it catching only two of his three targets for 22 yards. Samuel also ran the ball five times for only 13 yards.

49ers QB Brock Purdy (shoulder) is active for tonight’s game vs. the Bills. He had a good week by all accounts, progressing to a full practice on Friday. There’s still elevated risk to using Purdy in fantasy lineups with the throwing shoulder issue, though. And the spot is tough against the Bills’ ninth-ranked QB defense in wintery Buffalo. Purdy is not a recommended QB1 play – but his return is good news for San Francisco’s skill-position players. QB Brandon Allen is inactive as the emergency third QB tonight, leaving QB Josh Dobbs as the backup.

ESPN's Adam Schefter confirms that 49ers QB Brock Purdy (shoulder) is expected to start tonight's game vs. the Bills. Purdy progressed to a full practice on Friday and has not experienced any setbacks since, per Schefter. Purdy's return is excellent news for San Francisco's offense. But we'd try not to use Purdy in 1-QB leagues with the shoulder issue and a tough matchup against the Bills in what's expected to be a cold and potentially snowy game. The 49ers are still implied for only 19.25 points.

49ers QB Brock Purdy (shoulder) is listed as questionable for Sunday night's game vs. the Bills. But he put in a full practice on Friday, and HC Kyle Shanahan said afterward that Purdy is on track to play. “Lots of things can happen between now and then, but right now he's playing,” Shanahan said. We'll look for further updates on Purdy's status. But between the injury to his throwing shoulder and the matchup with Buffalo's ninth-ranked QB defense, Purdy is not a recommended QB1 play this week. San Francisco is currently implied for only 19.25 points -- tied for fifth fewest on the week.