49ers HC Kyle Shanahan said after Sunday night's loss to the Bills that RB Christian McCaffrey has a PCL injury that could be season-ending. McCaffrey will likely undergo additional testing on Monday to get a better look at the damage. We should get another update on his status over the next 24 hours. McCaffrey's absence would leave Jordan Mason as San Francisco's lead back once again. He out-carried RB Isaac Guerendo 13 to four in Buffalo. Mason, who's rostered in only 37% of Sleeper leagues, is the top target on waiver wires this week.

49ers RB Christian McCaffrey totaled 19 touches and 107 yards in Sunday’s win over Tampa Bay. He played over 80% of the snaps in his 2024 debut.

49ers RB Christian McCaffrey (Achilles) is listed as questionable for this weekend’s game against the Buccaneers. He practiced all week, including a full workout on Friday. HC Kyle Shanahan said again on Friday that McCaffrey is fully expected to play against Tampa Bay. We’ll keep an eye out for any reports on his expected workload in his 2024 debut. But unless we hear that his touches will be very limited, McCaffrey belongs in Week 10 fantasy lineups. RB Jordan Mason (shoulder) is off the final injury report and will also play vs. the Bucs.