FantasyPros Accuracy Award

2025 Accuracy Award Winner

Close FantasyPros Accuracy Award
Open Nav
Players
    Articles
      Shark Bites
        Show Navigation
        Show Menu
        FANTASY FOOTBALL NEWS

        Isaac Guerendo Out "A Few Weeks" With Shoulder Injury

        By Jared Smola | Updated on Mon, Aug 4 2025 7:31 PM UTC
        Isaac Guerendo Headshot

        49ers RB Isaac Guerendo is expected to miss "a few weeks" with a shoulder injury suffered in training camp, HC Kyle Shanahan said Monday. We're about a month away from the start of the regular season, so it sounds like Guerendo has a chance to be ready for Week 1. But we'll keep tabs on his status.

        2025 Fantasy Football Impact

        Guerendo has been the leader in the clubhouse to open the season as San Francisco's No. 2 RB after flashing as a rookie last year. He averaged 5.0 yards per carry and 10.1 yards per catch. And in four games with a snap rate north of 50%, he posted:

        • 102 total yards and a score
        • 128 total yards and two TDs
        • 75 total yards
        • 99 total yards

        But this injury creates an opportunity for San Francisco's other backs to gain ground on Guerendo. Fifth-round rookie Jordan James looks like the biggest threat. He missed a few days recently with a knee injury but returned to practice on Monday.

        We'll continue to keep a close eye on the situation. The 49ers' No. 2 RB has plenty of handcuff appeal, but fantasy drafters have been a little too certain that Guerendo will be that guy.

        Other Winners & Losers

        The uncertainty down the depth chart can't be bad news for RB Christian McCaffrey, who figures to be as busy as ever for as long as he's healthy this season.

        Jared Smola Author Image
        Jared Smola, Lead Analyst
        Jared has been with Draft Sharks since 2007. He’s now Lead Analyst, heading up the preseason and weekly projections that fuel your Draft War Room and in-season tools. He currently ranks ninth among 173 analysts in draft rankings accuracy.
        Week 7 Matchups That Matter: Get-Right Spot For Jayden Daniels

        Week 7 Matchups That Matter: Get-Right Spot For Jayden Daniels

        10:10am UTC 10/19/25

        A quick look at the most important matchup data to consider when making Week 7 start/sit decisions. Projected points, WR-CB matchup upgrades and downgrades, and more!

        Read More »
        Week 7 IDP Hits: Who's Your LB Now?

        Week 7 IDP Hits: Who's Your LB Now?

        8:12pm UTC 10/18/25

        Injuries, returns, and lineup renovations meant a lot of playing-time changes in Week 6. Who should you grab? Who should you dump? And what still might change again?

        Read More »
        Week 7 Wide Receiver Preview: Tetairoa McMillan’s Hot Streak Meets a Tough Matchup

        Week 7 Wide Receiver Preview: Tetairoa McMillan’s Hot Streak Meets a Tough Matchup

        4:09pm UTC 10/17/25

        From rookies in plus spots to vets with proven ceilings, these WRs have the matchups to rack up points in Week 7.

        Read More »
        Money Back You have our personal money-back guarantee: If you’re not happy with our service for any reason, just reach out by December 31, 2025, and we’ll give you 100% of your subscription money back. No strings attached.  You can cancel with one-click from your account page anytime.
        Compare Plans » Compare Plans »