Joe Mixon Out, Dameon Pierce Questionable For Week 5

Texans RB Joe Mixon (ankle) is out for Sunday's game vs. the Bills. After returning to a limited practice last Friday, he didn't take the field at all this week. RB Dameon Pierce (hamstring) put in a limited practice on Friday, his first since going down in Week 1. He's listed as questionable to face Buffalo. We're not expecting Pierce to play, but if he does, this will be a stay-away backfield in fantasy lineups. Cam Akers will be in the RB3 mix if Pierce ends up inactive.