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        Christian McCaffrey Questionable For Week 1

        By Jared Smola | Updated on Fri, Sep 5 2025 9:13 PM UTC
        Christian McCaffrey Headshot

        49ers RB Christian McCaffrey (calf) is listed as questionable for this weekend's game vs. the Seahawks. He was added to the injury report and limited in practice on Thursday and officially did not practice on Friday. McCaffrey was on the field going through warmups at the start of Friday's practice, though, and looked reasonably healthy. We'll surely get multiple updates on McCaffrey between now and kickoff on Sunday. Hopefully he's not a game-time decision, though, because 49ers-Seahawks doesn't kick off until 4:05 pm ET. McCaffrey's absence would leave Brian Robinson as San Francisco's lead back, although it's unclear exactly how big a role he'd be ready for after joining the team on August 22. RB Isaac Guerendo will also be available for the 'Niners, but RB Jordan James (finger) is doubtful.

        Jared Smola Author Image
        Jared Smola, Lead Analyst
        Jared has been with Draft Sharks since 2007. He’s now Lead Analyst, heading up the preseason and weekly projections that fuel your Draft War Room and in-season tools. He currently ranks ninth among 173 analysts in draft rankings accuracy.
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