The 49ers have voided the more than $25 million guaranteed for 2026 in WR Brandon Aiyuk's contract, according to The Athletic. Aiyuk reportedly skipped meetings and other activities in recent months, as he's continued to work back from his October 2024 knee injury. Aiyuk will not be contesting the voided money. There have been "repeated overtures from team officials and even players to try to bring Aiyuk back into the fold," per The Athletic. But "it’s now likely that the 27-year-old has played his last game with the franchise." Aiyuk is expected to be released after the season.

49ers WR Brandon Aiyuk (knee) is "not close" to returning, HC Kyle Shanahan said in a Thursday radio appearance. "There's no absolutes on these things," Shanahan said. "He's gotta continue to hit markers. He's tracking well, we'll be a better team when Brandon's out there... But it's not close." Shanahan said back in mid-August that "around Week 6" was when he was expecting to get Aiyuk back, but it's sounding like it could be later than that. Aiyuk is working back from a torn ACL and MCL suffered last October. If you've been stashing him in fantasy, try to hang on to him. But don't expect Aiyuk to be a contributor before the back half of the season.

The San Francisco 49ers have placed WR Brandon Aiyuk on the PUP list, according to Adam Schefter of ESPN. He’ll miss at least the four weeks of the season.

Former Kansas City WR Skyy Moore has been traded to the San Francisco 49ers, according to Adam Schefter of ESPN.

Niners HC Kyle Shanahan told reporters Monday that all the team's "ACL guys" -- in the words of The Athletic's Matt Barrows -- are on track to return around Week 6. That includes WR Brandon Aiyuk, of course.

49ers GM John Lynch stated that he "doesn't think" WR Brandon Aiyuk will be cleared for Week 1. Aiyuk tore his ACL and MCL last October in Week 7. Week 1 will mark a little over 10 months since sustaining the injury. There has been no official timeline laid out by the team for Aiyuk's return.

Per beat writer Matt Barrows, 49ers rookie WR Jordan Watkins is "in position to be the 49ers’ No. 3 or 4 wide receiver and perhaps serve as the team’s primary punt returner.” Teammates have reportedly praised his "maturity and mental sharpness." There’s some appeal here in the deepest of fantasy leagues, especially with San Francisco banged up at WR. Brandon Aiyuk remains without a timetable to return, while Ricky Pearsall and Jauan Jennings have dealt with summer injuries. Ultimately, Watkins is best viewed as a dynasty stash.

According to ESPN’s Nick Wagoner, the 49ers are still unsure when WR Brandon Aiyuk will return. Aiyuk suffered a multi-ligament knee injury back in Week 7 of the 2024 campaign. With WR Deebo Samuel now in Washington, there are plenty of targets available in San Francisco.